Description

Trimipramine-D3 is a deuterated analog of the tricyclic antidepressant Trimipramine, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Trimipramine in complex biological matrices using advanced analytical techniques. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, ensuring reliable data for drug metabolism studies, pharmacokinetic research, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the quantification of Trimipramine in plasma, serum, and other biological fluids.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic & Clinical Toxicology: Used in analytical methods for the precise determination of Trimipramine levels in forensic investigations and therapeutic drug monitoring (TDM).
• Bioanalytical Method Development & Validation: Serves as a critical reference material for developing, validating, and ensuring the robustness of quantitative bioanalytical assays.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assays for Trimipramine drug substance and product manufacturing.
• Reference Material for Certified Standards: Acts as a high-purity starting material for the preparation of certified reference materials (CRMs) and calibration standards.

Basic Information

Product Name	Trimipramine-D3
CAS No.	136765-54-3
Molecular Formula	C20H23D3N2
Molecular Weight	297.45 g/mol (approx.)
Synonyms	5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[b,f]azepine-2,3,4-trideuterio; Trimipramine-d3; Trimipramine (phenyl-2,3,4-d3); Deuterated Trimipramine; Trimipramine Internal Standard; 2,3,4-Trideutero-5-(3-dimethylamino-2-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
EINECS	Contact for details

Quality Control

Every batch of Trimipramine-D3 is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the product meets the high-purity requirements for use as an internal standard. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and the absence of interfering impurities. Our quality systems are designed to support compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.