Description

Protriptyline-D3 is a deuterium-labeled analog of the tricyclic antidepressant protriptyline, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and forensic toxicology departments for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference compound for the precise quantification of protriptyline and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in method development and validation for the detection and confirmation of tricyclic antidepressants in forensic investigations and clinical overdose cases.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assay methods during drug development and manufacturing.
• Biomedical Research: Facilitates research into the pharmacological mechanisms and biochemical pathways of tricyclic antidepressants.

Basic Information

Product Name	Protriptyline-D3
CAS No.	136765-50-9
Molecular Formula	C19H18D3N
Molecular Weight	266.40 g/mol
Synonyms	Protriptyline-d3; 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-3-(tricyclo[3.3.1.13,7]dec-1-yl)-, (3-2H3)-; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine-d3; Methyl-d3 Protriptyline; Deuterated Protriptyline; Protriptyline Internal Standard; Vivactil-d3
EINECS	Contact for details

Quality Control

Every batch of Protriptyline-D3 is manufactured and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity	≥95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.