Description

(+/-)-Propoxyphene-D5 CAS NO 136765-49-6 is a deuterated internal standard of the analgesic propoxyphene, where five hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for ensuring analytical accuracy and reliability in quantitative mass spectrometry. It is an essential reference material for pharmaceutical research, forensic toxicology, and clinical laboratories conducting drug metabolism and pharmacokinetic (DMPK) studies. The compound provides unmatched precision for the detection and quantification of propoxyphene and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry for accurate propoxyphene analysis.
• Forensic Toxicology: Used in post-mortem and human performance testing to confirm and quantify propoxyphene exposure with high specificity.
• Pharmaceutical R&D: Supports drug metabolism studies (ADME), pharmacokinetic profiling, and bioanalytical method development and validation.
• Clinical Research: Enables precise monitoring of propoxyphene levels in patient plasma or serum for therapeutic drug monitoring (TDM) and compliance studies.
• Reference Material Manufacturing: Serves as a certified component in the production of quality control and proficiency testing materials for laboratories.
• Regulatory Compliance Testing: Facilitates testing compliant with FDA, EMA, and other global regulatory guidelines for bioanalytical method validation.

Basic Information

Product Name	(+/-)-Propoxypyne-D5
CAS No.	136765-49-6
Molecular Formula	C22H24D5NO2
Molecular Weight	342.52 g/mol
Synonyms	Propoxyphene-d5; Dextropropoxyphene-d5; α-d-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol Propionate Ester-d5; (±)-Propoxyphene-d5; [2S-[2α(R*),3α]]-1-Benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate-d5; 4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate ester-d5; Darvon-d5 (deuterated)
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Propoxyphene-D5 is manufactured and tested to meet the stringent requirements for certified reference materials (CRMs). Our quality assurance includes comprehensive analytical characterization using NMR, HPLC, and mass spectrometry to confirm isotopic purity (≥98% D5) and chemical purity (≥95%). Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, assay, and purity. Our processes support compliance with ISO 17034 and ISO/IEC 17025 standards for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For daily use, allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. The material should be stored in a dedicated freezer, segregated from non-labeled compounds.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D5)	≥ 98%
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.