Description

Nitrazepam-D5 is a deuterated internal standard of the benzodiazepine sedative-hypnotic, Nitrazepam, specifically designed for analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical research sectors who require precise measurement of Nitrazepam in complex matrices.

Application

• Quantitative Mass Spectrometry: Serves as an internal standard for the accurate quantification of Nitrazepam in biological samples (e.g., plasma, urine, hair) and pharmaceutical formulations using LC-MS/MS or GC-MS.
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic studies, drug metabolism research, and bioequivalence testing to track and measure Nitrazepam levels with high precision.
• Forensic and Clinical Toxicology: Enables reliable detection and measurement of Nitrazepam in cases of drug-facilitated crimes, overdose investigations, and therapeutic drug monitoring.
• Method Development and Validation: Critical for developing, optimizing, and validating new analytical methods, ensuring they meet regulatory standards for specificity and accuracy.
• Reference Standard for Impurity Profiling: Can be used as a reference marker in the identification and quantification of related substances or degradation products in drug substances.
• Doping Control Analysis: Supports anti-doping laboratories in the detection of prohibited benzodiazepines in athlete samples.

Basic Information

Product Name	Nitrazepam-D5
CAS No.	136765-45-2
Molecular Formula	C15H6D5N3O3
Molecular Weight	286.29 g/mol
Synonyms	1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one-d5; Nitrazepam (phenyl-d5); Nitrazepam-d5 (Phenyl Ring Deuterated); 5-(2H5)Phenyl-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; Mogadon-d5; Alodorm-d5; Apodorm-d5; Surem-d5
EINECS	Contact for details

Quality Control

Our Nitrazepam-D5 is manufactured under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing chemical purity, isotopic purity (D-enrichment), and analytical results from techniques such as NMR, HPLC, and MS. We support compliance with GLP and ISO 17025 standards for forensic and pharmaceutical testing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.