Description

Maprotiline-D3 is a deuterated analog of the tetracyclic antidepressant maprotiline, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative analysis of maprotiline in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of maprotiline.
• Bioanalytical Method Development and Validation: Enables the creation of precise and robust analytical methods for therapeutic drug monitoring (TDM) and clinical trials.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of metabolites or related substances in drug substance and product testing.
• Forensic and Toxicology Analysis: Supports accurate quantification in forensic investigations involving maprotiline.
• Reference Material for Certified Standards: Used by manufacturers of certified reference materials (CRMs) to produce high-purity calibration standards.

Basic Information

Product Name	Maprotiline-D3
CAS No.	136765-39-4
Molecular Formula	C20H20D3N
Molecular Weight	284.42 g/mol
Synonyms	1-(3-Methylaminopropyl)dibenzo[b,e]bicyclo[2.2.2]octadiene-2,3,4,9,10,10-hexadeuterio; Maprotiline-d3; Deuterated Maprotiline; 3-(9,10-Dihydro-9,10[1',2']-benzeno-9-anthryl)-N-methyl-1-propanamine-d3; Ludiomil-d3 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Maprotiline-D3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Specifications typically include identity confirmation by spectroscopic methods, quantitative determination of isotopic purity (e.g., ≥98 atom % D), and chemical purity by HPLC. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.