Description

Hydromorphone-D3 is a stable isotope-labeled analog of the potent opioid analgesic, hydromorphone, where three hydrogen atoms are replaced by deuterium. This product is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based assays. It is primarily required by pharmaceutical research laboratories, forensic toxicology units, and clinical diagnostic facilities for drug metabolism studies, pharmacokinetic analysis, and precise bioanalytical measurements.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of hydromorphone in biological matrices (plasma, serum, urine).
• Metabolite identification and drug metabolism studies in pharmaceutical R&D.
• Forensic analysis and toxicology screening for accurate substance identification and quantification.
• Pharmacokinetic and bioequivalence studies in clinical research.
• Quality control and method validation in analytical laboratories.
• Stable isotope dilution analysis for high-precision measurement.

Basic Information

Product Name	Hydromorphone-D3
CAS No.	136765-37-2
Molecular Formula	C17H18D3NO3
Molecular Weight	288.38 g/mol (approx.)
Synonyms	Dihydromorphinone-D3; 4,5α-Epoxy-3-hydroxy-17-methylmorphinan-6-one-D3; [2H3]-Hydromorphone; Hydromorphone (phenyl-d3); Deuterated Hydromorphone; Hydromorphone-d3 Internal Standard; 14-Hydroxydihydromorphinone-D3
EINECS	Contact for details

Quality Control

Our Hydromorphone-D3 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of interfering substances. We adhere to relevant standards for high-purity reference materials to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.