Description

Haloperidol-D4 is a deuterium-labeled analog of the antipsychotic drug Haloperidol, serving as a critical internal standard for precise quantitative analysis. This high-purity reference material is essential for ensuring accuracy and reliability in sensitive analytical techniques. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioanalytical assays.

Application

• Internal Standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) analysis in bioequivalence and pharmacokinetic studies.
• Quantitative reference material for drug metabolism and disposition (DMPK) research.
• Calibration standard in forensic toxicology and clinical drug monitoring assays.
• Critical component in the development and validation of analytical methods according to ICH and FDA guidelines.
• Use in stable isotope dilution analysis to achieve superior accuracy in complex biological matrices.
• Research applications in studying the pharmacological profile and metabolic pathways of Haloperidol.

Basic Information

Product Name	Haloperidol-D4
CAS No.	136765-35-0
Molecular Formula	C21H19D4ClFNO2
Molecular Weight	379.88 g/mol (deuterated form)
Synonyms	4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone-d4; Haloperidol (phenyl-d4); 1-(4-Fluorophenyl-d4)-4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]butan-1-one; Haloperidol-d4 (Major); Deuterated Haloperidol; Haloperidol Internal Standard
EINECS	Contact for details

Quality Control

Our Haloperidol-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and confirming identity. We adhere to relevant industry standards for reference materials, and our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Keep the container tightly sealed in a desiccated atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.