Description

Dothiepin-D3 is a deuterium-labeled analog of dothiepin, a tricyclic antidepressant, serving as a critical stable isotope-labeled internal standard for analytical chemistry. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative analyses in complex matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for applications in method development, pharmacokinetic studies, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of dothiepin and its metabolites in bioanalytical studies (plasma, serum, urine).
• Pharmaceutical Research & Development: Critical for drug metabolism and pharmacokinetics (DMPK) studies, enabling accurate tracking of the parent compound.
• Forensic and Clinical Toxicology: Supports the development and validation of highly specific and sensitive assays for antidepressant screening and confirmation.
• Method Development and Validation: Provides a stable, non-interfering reference point to improve the precision, accuracy, and robustness of analytical methods.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for pharmaceutical quality control laboratories.
• Reference Material for Certified Standards: Serves as a primary material for the preparation of certified reference materials (CRMs) and calibration standards.

Basic Information

Product Name	Dothiepin-D3
CAS No.	136765-31-6
Molecular Formula	C19H18D3NS
Molecular Weight	298.46 g/mol
Synonyms	Dosulepin-d3; Dothiepin (phenyl-d3); 11-(3-Dimethylaminopropylidene)-6H-dibenzo[b,e]thiepin-d3; Prothiaden-d3; 1-Propanamine, N,N-dimethyl-3-dibenzo[b,e]thiepin-11(6H)-ylidene-, phenyl-d3; Deuterated Dothiepin; Dothiepin Internal Standard
EINECS	Contact for details

Quality Control

Our Dothiepin-D3 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including NMR and mass spectrometry for isotopic enrichment confirmation and HPLC for chemical purity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.