Description

α-Hydroxyalprazolam-D5 is a deuterated analog of the primary metabolite of the pharmaceutical substance alprazolam, serving as a critical stable isotope-labeled internal standard. This compound is essential for ensuring the accuracy and reliability of quantitative analytical methods, particularly in regulated environments. It is primarily used by analytical laboratories and research institutions in the pharmaceutical and forensic toxicology sectors for method development, validation, and high-precision analysis.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of alprazolam and its metabolites.
• Method development and validation in pharmaceutical bioanalysis for pharmacokinetic and metabolism studies.
• High-accuracy calibration in forensic and clinical toxicology laboratories for drug testing and compliance monitoring.
• Quality control and assurance in the manufacturing of active pharmaceutical ingredients (APIs) and finished dosage forms.
• Research applications in studying the metabolic pathways and disposition of benzodiazepine-class drugs.
• Reference material for proficiency testing and accreditation programs in analytical laboratories.

Basic Information

Product Name	α-Hydroxyalprazolam-D5
CAS No.	136765-24-7
Molecular Formula	C17H8D5ClN4O
Molecular Weight	329.80 g/mol
Synonyms	8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-one, α-hydroxy, pentadeuterated; α-Hydroxyalprazolam-d5; Alprazolam Metabolite D5; 1-Methyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-4-one α-hydroxy-d5; Hydroxyalprazolam-d5; α-OH-Alprazolam-d5; [1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-1-methyl-6-phenyl-, 4-one, α-hydroxy-, pentadeuterated
EINECS	Contact for details

Quality Control

Our α-Hydroxyalprazolam-D5 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and conformity to specifications. Certificates of Analysis (COA) detailing results for identity, assay, isotopic purity, and related substances are provided and traceable to certified reference materials where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.