Description

1,2-Bis((2R,5R)-2,5-Di-I-Propylphospholano)Ethane, Min. 97% is a high-purity, chiral bisphosphine ligand of significant importance in asymmetric catalysis. This compound matters for its exceptional ability to induce stereoselectivity in transition metal-catalyzed reactions, enabling the production of enantiomerically pure intermediates. Pharmaceutical, agrochemical, and fine chemical manufacturers need this ligand for developing and scaling up advanced synthetic routes, particularly in hydrogenation and cross-coupling processes. Its defined stereochemistry and high purity are critical for achieving reproducible and efficient catalytic performance.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Agrochemical Manufacturing: Employed in the production of chiral herbicides, fungicides, and insecticides.
• Fine Chemical Production: Facilitates the creation of specialty chemicals, flavors, and fragrances with specific stereochemistry.
• Academic & Industrial R&D: Serves as a critical research tool in methodology development for new catalytic transformations.
• Catalyst Library Development: A component in high-throughput screening for discovering new asymmetric catalysts.

Basic Information

Item	Detail
Product Name	1,2-Bis((2R,5R)-2,5-Di-I-Propylphospholano)Ethane, Min. 97%
CAS No.	136705-63-0
Molecular Formula	C22H44P2
Molecular Weight	370.53 g/mol
Synonyms	(R,R)-DIPAMP; (2R,2'R,5R,5'R)-1,1'-(1,2-Ethanediyl)bis[2,5-di-1-propylphospholane]; DuPhos-type ligand; DIPAMP ligand; Chiral bisphospholane; (R,R)-1,2-Bis(2,5-diisopropylphospholano)ethane; (R,R)-1,2-Bis[(2,5-diisopropylphospholan-1-yl)]ethane
EINECS	Contact for details

Quality Control

Our 1,2-Bis((2R,5R)-2,5-Di-I-Propylphospholano)Ethane is manufactured under strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes rigorous analytical testing, including chiral HPLC and NMR spectroscopy, to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient conditions should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Enantiomeric Purity	Min. 99.0% ee
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.