Description

(+)-1,2-Bis((2R,5R)-2,5-Diethylphospholano)Ethane is a high-purity, chiral bidentate phosphine ligand of significant importance in asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in hydrogenation and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation Catalyst Ligand: A key component for rhodium and ruthenium complexes used in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral active pharmaceutical ingredients (APIs), including β-amino acids and other complex molecules.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables asymmetric C-C bond formation and other catalytic processes for high-value fragrance and flavor ingredients.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and optimizing existing synthetic routes for scale-up.
• Chiral Auxiliary and Reagent: Can be employed in stoichiometric or catalytic amounts to induce chirality in complex molecular frameworks.

Basic Information

Product Name	(+)-1,2-Bis((2R,5R)-2,5-Diethylphospholano)Ethane
CAS No.	136705-62-9
Molecular Formula	C20H40P2
Molecular Weight	342.48 g/mol
Synonyms	(R,R)-Et-DuPhos; (2R,2'R,5R,5'R)-1,1'-(1,2-Ethanediyl)bis[2,5-diethylphospholane]; (+)-1,2-Bis((2R,5R)-2,5-diethylphospholano)ethane; (R,R)-1,2-Bis(2,5-diethylphospholano)ethane; DuPhos ligand (Et-DuPhos variant); (R,R)-Et-DuPHOS; ChiraPhos Et; 1,2-Ethanediylbis[(2R,5R)-2,5-diethylphospholane]
EINECS	Contact for details

Quality Control

Our (+)-1,2-Bis((2R,5R)-2,5-Diethylphospholano)Ethane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for catalytic performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profile. We adhere to cGMP standards where applicable to support our clients' regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.