Description

α-Defensin-3 (Human) is a cationic antimicrobial peptide belonging to the defensin family, a critical component of the innate immune system. This high-purity peptide is essential for research and development in immunology and infectious disease, providing a key tool for studying host defense mechanisms. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in developing novel anti-infective and immunomodulatory therapies.

Application

• Biomedical Research: Fundamental studies on innate immunity, neutrophil function, and antimicrobial mechanisms of action.
• Drug Discovery: Serving as a lead compound or reference standard in the development of new antibiotic and antiviral agents.
• Diagnostic Development: Use as a critical reagent in assay development for inflammatory and infectious disease biomarkers.
• Cell Culture & In Vitro Studies: Investigation of peptide interactions with cell membranes and its role in cellular defense pathways.
• Biochemical Reagent: A high-purity standard for analytical method development and validation in peptide analysis.

Basic Information

Product Name	α-Defensin-3 (Human)
CAS No.	136661-76-2
Molecular Formula	C206H342N62O57S6
Molecular Weight	~ 4.9 kDa
Synonyms	Human Neutrophil Peptide 3; HNP-3; Defensin, Alpha 3; DEFA3; HP-3; Neutrophil Defensin 3; Antimicrobial Peptide HNP-3; Cryptdin-3 (related murine homolog); Myeloid Antimicrobial Peptide; NP-3
EINECS	Contact for details

Quality Control

Our α-Defensin-3 (Human) is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to relevant guidelines for research-grade bioactive peptides to support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	4.9 kDa ± 1 Da (MALDI-TOF)
Solubility	Soluble in water or aqueous buffers
Endotoxin Level	< 1.0 EU/mg
Biological Activity	Determined by antimicrobial assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.