Description

8-Hydroxycarvedilol o-Glucuronide is a major, pharmacologically relevant metabolite of the β-blocker carvedilol. This compound matters significantly for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of bioanalytical methods. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug research, metabolite identification, and impurity profiling.

Application

• Reference Standard for Bioanalysis: Critical for the development and validation of HPLC, LC-MS, and LC-MS/MS methods to quantify carvedilol and its metabolites in biological matrices like plasma and urine.
• Metabolite Profiling & Identification: Used as an authentic standard to identify and characterize metabolites in in vitro (e.g., liver microsomes) and in vivo studies, supporting ADME (Absorption, Distribution, Metabolism, Excretion) research.
• Pharmaceutical Impurity Standard: Serves as a known impurity or degradation product reference in the quality control of carvedilol active pharmaceutical ingredient (API) and finished dosage forms to ensure product safety and compliance.
• Pharmacokinetic & Pharmacodynamic Studies: Enables the investigation of the exposure-response relationship and the contribution of metabolites to the overall therapeutic and side-effect profile of carvedilol.
• Drug-Drug Interaction Studies: Utilized in studies assessing the impact of other drugs on the metabolic pathways of carvedilol, which is metabolized by enzymes like UGTs (UDP-glucuronosyltransferases) and CYPs.
• Regulatory Submissions: Provides essential data and reference materials for regulatory filings (e.g., with the FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.

Basic Information

Product Name	8-Hydroxycarvedilol o-Glucuronide
CAS No.	136657-39-1
Molecular Formula	C32H40N2O11
Molecular Weight	628.67 g/mol
Synonyms	8-Hydroxycarvedilol Glucuronide; Carvedilol Metabolite M2; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Glucuronide; (8R)-8-Hydroxycarvedilol O-Glucuronide; BM 14190 Glucuronide; Carvedilol Glucuronide Metabolite; 8-β-Hydroxycarvedilol O-Glucuronide
EINECS	Contact for details

Quality Control

Our 8-Hydroxycarvedilol o-Glucuronide is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical reference materials. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥95.0% (Area Percent)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.