Description

1-Hydroxycarvedilol o-Glucuronide is a key glucuronidated metabolite of the widely used β-blocker carvedilol. This compound matters significantly for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of carvedilol metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance mechanisms, and bioavailability of carvedilol.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for accurate detection and quantification in plasma, serum, and urine.
• Metabolite Identification & Characterization: Essential for structural confirmation and profiling of carvedilol metabolites during preclinical and clinical development stages.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential activity of carvedilol metabolites.
• Impurity Profiling: Can be utilized as a marker to monitor and control related substance impurities in carvedilol active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	1-Hydroxycarvedilol o-Glucuronide
CAS No.	136657-37-9
Molecular Formula	C30H38N2O11
Molecular Weight	602.63 g/mol
Synonyms	1'-Hydroxycarvedilol O-Glucuronide; Carvedilol Metabolite M14; Carvedilol Glucuronide; 1'-Hydroxy Carvedilol Glucuronide; (2RS)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol 1'-O-Glucuronide; 1'-OH-Carvedilol O-Glucuronide; 1-Hydroxy Carvedilol O-Glucuronide
EINECS	Contact for details

Quality Control

Our 1-Hydroxycarvedilol o-Glucuronide is manufactured under strict quality systems suitable for research and analytical applications. Each batch undergoes rigorous identity confirmation, purity analysis, and impurity profiling using advanced techniques like HPLC and LC-MS. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for purity, related substances, and residual solvents to ensure traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.