Description

Pyrrolidine, 1-(Fluoroacetyl)-2,5-Dimethyl-, (2R-Trans)- (9Ci) is a chiral, fluorinated pyrrolidine derivative, a high-value building block in advanced organic synthesis. Its core value lies in its unique stereochemistry and the reactive fluoroacetyl group, enabling precise molecular construction for complex targets. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring structure-activity relationships. The CAS number for this specific stereoisomer is 136634-11-2.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom and specific stereochemistry enhance biological activity and stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fluorine Chemistry Research: A valuable compound for studying the introduction and effects of fluorine atoms in complex molecular frameworks, relevant for material science and medicinal chemistry.
• Peptidomimetics & Bioactive Molecule Design: The pyrrolidine scaffold is a common motif in drug design, making this fluorinated derivative useful for creating protease inhibitors and other bioactive compounds.

Basic Information

Product Name	Pyrrolidine, 1-(Fluoroacetyl)-2,5-Dimethyl-, (2R-Trans)- (9Ci)
CAS No.	136634-11-2
Molecular Formula	C8H14FNO2
Molecular Weight	175.20 g/mol
Synonyms	(2R,5R)-1-(Fluoroacetyl)-2,5-dimethylpyrrolidine; (2R-trans)-1-(Fluoroacetyl)-2,5-dimethylpyrrolidine; 1-Fluoroacetyl-2,5-dimethylpyrrolidine, (2R,5R)-; 2,5-Dimethyl-1-(fluoroacetyl)pyrrolidine, (2R,5R)-; (R,R)-1-(Fluoroacetyl)-2,5-dimethylpyrrolidine; trans-1-(Fluoroacetyl)-2,5-dimethylpyrrolidine; Fluoromethyl 2,5-dimethylpyrrolidin-1-yl ketone
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 1-(Fluoroacetyl)-2,5-Dimethyl-, (2R-Trans)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), chiral content, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.