Description

Fmoc-D-Cpg-Oh CAS NO 136555-16-3 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the D-isomer of the non-proteinogenic amino acid cyclopropylglycine into peptide chains, enabling the creation of complex, conformationally constrained peptides with enhanced metabolic stability and biological activity. It is an essential building block for research and development in pharmaceutical discovery, particularly for the synthesis of peptide-based therapeutics, enzyme inhibitors, and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based drugs, including GPCR-targeted therapies and enzyme inhibitors.
• Conformationally Constrained Peptide Design: Incorporation of the D-cyclopropylglycine residue introduces structural rigidity to study structure-activity relationships (SAR).
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides for diagnostic or imaging applications.
• Academic and Institutional Research: Fundamental tool in biochemistry and medicinal chemistry laboratories for studying peptide function and interaction.

Basic Information

Product Name	Fmoc-D-Cpg-Oh
CAS No.	136555-16-3
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-D-cyclopropylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-cyclopropylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclopropylacetic acid; Fmoc-D-Cpg-OH; Fmoc-D-Cyclopropylglycine; N-Fmoc-D-cyclopropylglycine; D-Fmoc-cyclopropylglycine; Fmoc-(R)-2-amino-2-cyclopropylacetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Cpg-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via validated analytical methods such as HPLC, NMR, and MS. We support compliance with cGMP and ICH guidelines for critical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.