Description

Connexin 31 CAS NO 136362-16-8 is a synthetic peptide corresponding to a specific sequence of the Connexin 31 (GJB3) protein, a crucial component of gap junctions involved in cellular communication. This high-purity reference standard is essential for researchers and developers in life sciences, enabling precise biological studies and assay development. It is primarily utilized by pharmaceutical R&D teams, academic institutions, and diagnostic manufacturers focusing on dermatology, hearing, and neurological research.

Application

• Biochemical Research: Used as a critical reference standard in the study of gap junction structure, function, and intercellular signaling pathways.
• Antibody Production & Validation: Serves as a key immunogen and antigen for the development and specificity testing of antibodies targeting Connexin 31.
• Diagnostic Assay Development: Employed in the calibration and quality control of ELISA, Western Blot, and other immunoassays for detecting Connexin 31-related biomarkers.
• Drug Discovery Screening: Acts as a target compound in high-throughput screening (HTS) platforms to identify potential modulators of gap junction activity for therapeutic applications.
• Academic & Clinical Studies: Supports fundamental research into genetic skin disorders (e.g., erythrokeratodermia variabilis) and nonsyndromic hearing loss linked to GJB3 mutations.

Basic Information

Product Name	Connexin 31
CAS No.	136362-16-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Gap Junction β-3 Protein Peptide; GJB3 Peptide; Connexin-31 Peptide; CX31 Synthetic Fragment; Gap Junction Protein Beta 3 (GJB3) Fragment; Intercellular Communication Protein Peptide; 136362-16-8; Connexin 31 (GJB3) Reference Standard
EINECS	Contact for details

Quality Control

Our Connexin 31 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Solubility	Soluble in water or appropriate aqueous buffer
Single Peak on HPLC	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.