Description

Z-2-Bromo-4,4,4-Trifluorobutenoic Acid, Ethyl Ester is a high-value fluorinated organic building block characterized by its bromine and trifluoromethyl functional groups. This compound is essential for introducing specific structural motifs into target molecules, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display and lighting materials.
• Advanced Polymer Modification: Incorporated to impart unique solubility, surface energy, or chemical resistance properties to specialty polymers.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed coupling reactions (e.g., Suzuki, Heck) to create complex organic frameworks.
• Academic & Contract Research: Utilized in research laboratories for methodological development and exploring new synthetic pathways involving fluorinated olefins.

Basic Information

Product Name	Z-2-Bromo-4,4,4-Trifluorobutenoic Acid, Ethyl Ester
CAS No.	136264-28-3
Molecular Formula	C6H6BrF3O2
Molecular Weight	246.01 g/mol
Synonyms	(Z)-Ethyl 2-bromo-4,4,4-trifluorobut-2-enoate; Ethyl (Z)-2-Bromo-4,4,4-trifluorocrotonate; 2-Bromo-4,4,4-trifluorobut-2-enoic Acid Ethyl Ester (Z-isomer); (Z)-2-Bromo-4,4,4-trifluorobutenoic Acid Ethyl Ester; (Z)-2-Bromo-4,4,4-trifluorocrotonic Acid Ethyl Ester; Ethyl (Z)-2-Bromo-4,4,4-trifluorobut-2-enoate; Z-2-Bromo-4,4,4-trifluorocrotonic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Z-2-Bromo-4,4,4-Trifluorobutenoic Acid, Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Z-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.