Description

Pituitary Adenylate Cyclase Activating CAS NO 136134-68-4 is a synthetic peptide analog of the endogenous neuropeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide). This compound is a critical research tool for studying neuroendocrine signaling, vasodilation, and immune modulation pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, metabolic disorders, and drug discovery.

Application

• Neuroscience Research: Used as a standard agonist to study PAC1, VPAC1, and VPAC2 receptor signaling and function in the central and peripheral nervous systems.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool in high-throughput screening (HTS) assays for identifying novel therapeutics targeting PACAP-related disorders.
• Metabolic Studies: Applied in research investigating the role of PACAP in insulin secretion, glucose homeostasis, and energy metabolism.
• Cardiovascular Research: Utilized to explore its vasodilatory effects and potential in models of cerebral and coronary blood flow regulation.
• Immunology & Inflammation Research: Employed to examine the immunomodulatory functions of PACAP in cytokine release and inflammatory responses.
• Cell Culture & In Vitro Studies: Acts as a key reagent to stimulate cAMP production and other second messenger pathways in various cell lines.

Basic Information

Product Name	Pituitary Adenylate Cyclase Activating CAS NO 136134-68-4
CAS No.	136134-68-4
Molecular Formula	C112H179N35O34S
Molecular Weight	2505.9 g/mol
Synonyms	PACAP (1-27); Pituitary Adenylate Cyclase-Activating Polypeptide (1-27); PACAP-27; ADCYAP (1-27); PACAP 1-27 amide, human; PACAP-27, human; PACAP 1-27; H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
EINECS	Contact for details

Quality Control

Our Pituitary Adenylate Cyclase Activating CAS NO 136134-68-4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, ensuring it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.