Description

Fluconazole Glucuronide is a key metabolite of the widely used antifungal agent, fluconazole. This compound is of significant importance in pharmaceutical research and development, particularly for drug metabolism and pharmacokinetic (DMPK) studies. It serves as a critical reference standard for analytical laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification and identification of fluconazole metabolites in biological matrices.
• Drug Metabolism Studies: Essential for in vitro and in vivo studies to understand the metabolic pathways, clearance rates, and bioavailability of fluconazole.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and LC-MS/MS methods for clinical and preclinical trials.
• Toxicology and Safety Assessment: Employed in metabolite profiling and safety testing to assess potential toxicological implications of fluconazole metabolism.
• DMPK and ADME Research: Critical component in Absorption, Distribution, Metabolism, and Excretion (ADME) studies for new drug applications (NDAs).
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control of fluconazole active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	Fluconazole Glucuronide
CAS No.	136134-23-1
Molecular Formula	C22H24F2N6O8
Molecular Weight	538.46 g/mol
Synonyms	Fluconazole β-D-Glucuronide; Fluconazole Glucuronide Metabolite; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl β-D-Glucopyranosiduronic Acid; α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol β-D-Glucuronide; Fluconazole 1-O-β-Glucuronide; Fluconazole N-Glucuronide (if applicable); Diflucan Glucuronide (Metabolite)
EINECS	Contact for details

Quality Control

Our Fluconazole Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and reference applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every batch to guarantee traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.