Description

Boc-Arg-Val-Arg-Arg-Amc is a specialized, protected peptide substrate designed for biochemical research. This compound is critical for studying protease activity and enzyme kinetics, particularly for enzymes like furin and related proprotein convertases. It is an essential tool for researchers and developers in the fields of pharmaceutical discovery, proteomics, and molecular biology, where precise measurement of enzymatic cleavage is required.

Application

• Protease Activity Assays: A fluorogenic substrate for the continuous, sensitive measurement of furin and other serine protease activities in vitro.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for therapeutic development.
• Enzyme Kinetic Studies: Enables the determination of kinetic parameters (Km, Vmax, kcat) for target proteases, facilitating mechanistic studies.
• Biochemical Research: A key reagent in studying the role of proprotein convertases in viral entry (e.g., HIV, influenza) and other disease pathways.
• Diagnostic Development: Potential use in developing diagnostic kits for detecting specific protease activities associated with pathological conditions.
• Cell Biology: Used to monitor and quantify protease activity within cellular and tissue extracts.

Basic Information

Product Name	Boc-Arg-Val-Arg-Arg-Amc
CAS No.	136132-77-9
Molecular Formula	C38H66N16O8
Molecular Weight	851.04 g/mol
Synonyms	Boc-Arg-Val-Arg-Arg-AMC; t-Butyloxycarbonyl-Arginyl-Valyl-Arginyl-Arginyl-7-Amino-4-Methylcoumarin; Boc-RVRR-AMC; Boc-RVRR-AMC Fluorogenic Substrate; Furin Substrate Boc-RVRR-AMC; t-Boc-Arg-Val-Arg-Arg-AMC; Proprotein Convertase Substrate; PC Substrate
EINECS	Contact for details

Quality Control

Our Boc-Arg-Val-Arg-Arg-Amc is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.