Description

Fmoc-Tic-Oh CAS NO 136030-33-6 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) derivative of the non-proteinogenic amino acid Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid). This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide drug discovery, medicinal chemistry, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, stepwise construction of peptides.
• Peptide Drug Discovery: Used to incorporate the constrained Tic residue into novel peptide candidates to influence backbone conformation and biological activity.
• Medicinal Chemistry & SAR Studies: Serves as a key intermediate for structure-activity relationship studies, particularly for modulating receptor selectivity and metabolic stability.
• Synthesis of Peptide Mimetics: Essential for creating peptidomimetics where the Tic scaffold is used to replace natural amino acids to enhance drug-like properties.
• Research Biochemicals: Used in academic and industrial laboratories for synthesizing custom peptides for biological assays and target validation.
• Pharmaceutical Intermediate: Acts as a high-purity raw material in the GMP-compliant production of active pharmaceutical ingredients (APIs) for peptide-based drugs.

Basic Information

Product Name	Fmoc-Tic-Oh
CAS No.	136030-33-6
Molecular Formula	C25H21NO4
Molecular Weight	399.44 g/mol
Synonyms	Fmoc-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; Fmoc-Tic; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-(S)-Tic-OH; Fmoc-L-Tic-OH; Fmoc-Tic-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Tic-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.