Description

Pyridine,2-[Bis(Trimethylsilyl)Phosphino]-6-(Trimethylsilyl)-(9Ci) is a highly specialized organosilicon-phosphine ligand and reagent, valued for its unique steric and electronic properties in advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel catalysts and complex molecular architectures where precise control over reactivity is paramount. Its primary utility is found in pharmaceutical R&D, materials science, and fine chemical synthesis, particularly for cross-coupling reactions and the stabilization of reactive intermediates.

Application

• Ligand in Transition Metal Catalysis: Employed as a bulky, electron-donating phosphine ligand in palladium- and nickel-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Buchwald-Hartwig amination).
• Precursor for Phosphorus-Containing Compounds: Serves as a key synthon for the preparation of novel phosphines, phosphonium salts, and phosphorus-based ligands with tailored properties.
• Silylating Agent in Organic Synthesis: Used to introduce trimethylsilyl protecting groups or to modify the reactivity of substrates under mild conditions.
• Research & Development of New Materials: Applied in the synthesis of advanced materials, including molecular precursors for semiconductors and novel polymeric structures.
• Stabilization of Low-Coordinate Species: Utilized to stabilize reactive, low-valent metal complexes and other sensitive intermediates in organometallic chemistry.
• Asymmetric Synthesis: Potential use in the development of chiral catalysts and auxiliaries for enantioselective transformations.

Basic Information

Item	Details
Product Name	Pyridine,2-[Bis(Trimethylsilyl)Phosphino]-6-(Trimethylsilyl)-(9Ci)
CAS No.	135958-48-4
Molecular Formula	C14H30NP1Si3
Molecular Weight	327.64 g/mol
Synonyms	2-[Bis(trimethylsilyl)phosphino]-6-(trimethylsilyl)pyridine; 6-(Trimethylsilyl)-2-[bis(trimethylsilyl)phosphino]pyridine; 2,6-Bis(trimethylsilyl)pyridine phosphine derivative; (6-Trimethylsilyl-2-pyridyl)bis(trimethylsilyl)phosphine; TMS-PyPhos ligand; Silylated pyridine phosphine ligand; PSi3 ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of Pyridine,2-[Bis(Trimethylsilyl)Phosphino]-6-(Trimethylsilyl)-(9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the exacting standards of research and process development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by NMR and HPLC), identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture must be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (1H, 13C, 31P)
Purity (HPLC)	≥ 95% (Area %)
Purity (NMR)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.