Description

n-Fmoc-2-Aminoindan-2-Carboxylic Acid is a sophisticated, non-proteinogenic amino acid derivative widely used as a critical building block in advanced peptide synthesis. This compound is essential for introducing the constrained 2-aminoindane-2-carboxylic acid (Aic) scaffold, which is highly valued for its ability to stabilize specific peptide conformations and enhance metabolic stability. It is primarily utilized by pharmaceutical researchers, peptide chemists, and fine chemical manufacturers engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, enabling the incorporation of the conformationally rigid Aic residue into peptide chains.
• Peptidomimetic Drug Discovery: Used to create constrained peptide analogs with improved receptor selectivity, proteolytic stability, and pharmacokinetic properties for therapeutic targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold in the design and synthesis of novel bioactive molecules for oncology, neurology, and metabolic disease research.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides used as tools to study protein-protein interactions and enzyme mechanisms.
• API Intermediate Manufacturing: Acts as a high-purity intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) containing non-standard amino acids.

Basic Information

Product Name	n-Fmoc-2-Aminoindan-2-Carboxylic Acid
CAS No.	135944-07-9
Molecular Formula	C25H21NO4
Molecular Weight	399.44 g/mol
Synonyms	Fmoc-Aic-OH; Fmoc-2-Aminoindane-2-carboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminoindane-2-carboxylic Acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]indane-2-carboxylic Acid; (2R/S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)indane-2-carboxylic Acid; Fmoc-2-Aic-OH; N-Fmoc-2-aminoindan-2-carboxylic acid; Aic(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-2-Aminoindan-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis where applicable. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.