Description

Dl-n-Fmoc-2'-Methylphenylalanine CAS NO 135944-06-8 is a protected, non-natural amino acid derivative featuring an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine and a methyl substituent on the phenyl ring. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of modified phenylalanine residues to study structure-activity relationships and enhance peptide stability. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide drug candidates to modulate bioavailability, receptor binding affinity, and metabolic stability.
• Peptidomimetic Development: Serves as a key intermediate for creating non-natural peptide analogs with enhanced pharmacological properties.
• Biochemical Probes: Used in the synthesis of labeled or modified peptides for proteomics and enzyme interaction studies.
• Academic Research: A valuable reagent for studying protein folding, peptide libraries, and molecular recognition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP peptide production.

Basic Information

Product Name	Dl-n-Fmoc-2'-Methylphenylalanine
CAS No.	135944-06-8
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-2'-Me-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2'-methyl-DL-phenylalanine; DL-N-Fmoc-2'-Methylphenylalanine; 2'-Methyl-DL-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-2-methylphenylalanine; N-Fmoc-2'-methyl-DL-phenylalanine; (RS)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(2-methylphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Dl-n-Fmoc-2'-Methylphenylalanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.