Description

1-(4-tert-Butylphenyl)-2-Trimethylsilylethyne is a specialized organosilicon building block featuring a terminal alkyne group protected by a trimethylsilyl (TMS) moiety. This compound is of significant value in advanced organic synthesis, particularly in cross-coupling and cycloaddition reactions, due to its stability and reactivity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) via Sonogashira, Glaser, or Huisgen cycloaddition (click chemistry) reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that require arylacetylene motifs.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers, molecular wires, and organic light-emitting diodes (OLEDs) due to its acetylene functionality.
• Chemical Research: Employed in academic and industrial laboratories for methodology development in palladium-catalyzed cross-coupling and alkyne metathesis.
• Ligand & Catalyst Preparation: Useful for synthesizing sophisticated ligands and organometallic catalysts where a sterically hindered alkyne is required.
• Fine Chemical Production: Intermediate in the multi-step synthesis of dyes, flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	1-(4-tert-Butylphenyl)-2-Trimethylsilylethyne
CAS No.	135883-30-6
Molecular Formula	C15H22Si
Molecular Weight	230.42 g/mol
Synonyms	4-tert-Butylphenyl(trimethylsilyl)acetylene; 1-(4-(tert-Butyl)phenyl)-2-(trimethylsilyl)ethyne; (4-tert-Butylphenylethynyl)trimethylsilane; 1-Trimethylsilyl-2-(4-tert-butylphenyl)acetylene; p-tert-Butylphenyl(trimethylsilyl)acetylene; TMS-Protected 4-tert-Butylphenylacetylene; Silane, [(4-(1,1-dimethylethyl)phenyl)ethynyl]trimethyl-
EINECS	Contact for details

Quality Control

Our production of 1-(4-tert-Butylphenyl)-2-Trimethylsilylethyne adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for synthetic applications. Each lot is characterized by GC, HPLC, and NMR to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.