Description

Asenapine 13C D3 Hcl CAS NO 135883-15-7 is a stable isotope-labeled internal standard, specifically a deuterated and carbon-13 labeled form of the antipsychotic drug asenapine. This compound is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is an essential tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and forensic toxicology units requiring precise pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring.

Application

• Quantitative Bioanalysis (LC-MS/MS): Serves as a critical internal standard for the accurate quantification of asenapine in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion in clinical and pre-clinical trials.
• Drug Metabolism and Disposition Research: Used to study metabolic pathways and identify metabolites without interference from endogenous compounds.
• Forensic and Clinical Toxicology: Supports reliable screening and confirmation of asenapine in forensic investigations and overdose cases.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product.

Basic Information

Product Name	Asenapine 13C D3 Hcl
CAS No.	135883-15-7
Molecular Formula	C17H1313C2H3ClNO • HCl
Molecular Weight	Contact for details
Synonyms	(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C,2H3 hydrochloride; Asenapine-13C,d3 hydrochloride; Asenapine-d3-13C HCl; Asenapine (13C D3) Hydrochloride; SYCRIT-13C,d3 HCl; Org 5222-13C,d3 hydrochloride; SAPHRIS-13C,d3 internal standard
EINECS	Contact for details

Quality Control

Every batch of Asenapine 13C D3 Hcl is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR (1H, 13C), High-Resolution Mass Spectrometry (HRMS), and HPLC. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.