Description

(S,S)-Asenapine Maleate CAS NO 135883-08-8 is a high-purity, stereochemically defined active pharmaceutical ingredient (API) and a key intermediate in advanced pharmaceutical synthesis. This compound is critically important for research and development focused on novel antipsychotic therapeutics, particularly for the treatment of schizophrenia and bipolar disorder. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in neuropharmacology and process chemistry.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as a critical chiral building block for the production of Asenapine, an atypical antipsychotic medication.
• Reference Standard & Analytical Testing: Used as a certified reference material (CRM) for method development, validation, and quality control (QC) in pharmaceutical analysis.
• Process Research & Development (R&D): Essential for route scouting, optimization, and scale-up studies in pharmaceutical process chemistry.
• Metabolite & Impurity Studies: Employed in the synthesis and identification of related substances and degradation products for regulatory filings.
• Formulation Development: Used in pre-formulation studies to assess compatibility and stability in various drug delivery systems.
• Pharmacological Research: A key material for in-vitro and in-vivo studies investigating the mechanism of action and structure-activity relationships (SAR) of dopamine and serotonin receptor antagonists.

Basic Information

Product Name	(S,S)-Asenapine Maleate
CAS No.	135883-08-8
Molecular Formula	C28H30ClN3O4
Molecular Weight	508.01 g/mol
Synonyms	(3aRS,12bRS)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate; (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (Z)-2-butenedioate; Asenapine Maleate (S,S-isomer); Trans-Asenapine Maleate; Org 5222 Maleate; SCH 900222 Maleate
EINECS	Contact for details

Quality Control

Our (S,S)-Asenapine Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and stereochemical integrity, suitable for pharmaceutical R&D applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from tests including HPLC assay, chiral purity, residual solvents, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (S,S-Isomer)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.