Description

B18R Protein, Vaccinia Virus CAS NO 135847-80-2 is a recombinant protein derived from the vaccinia virus, specifically the B18R gene product, which functions as a type I interferon binding protein. This protein is a critical reagent in virology and immunology research, enabling the study of viral immune evasion mechanisms and enhancing the efficiency of viral vector-based systems. It is essential for researchers and developers in the fields of vaccine development, gene therapy, and fundamental virological studies, where precise control of the cellular interferon response is required.

Application

• Virology Research: Used to study vaccinia virus pathogenesis and host immune response evasion mechanisms.
• Cell Culture Enhancement: Added to cell culture media to neutralize type I interferons, improving the yield and stability of sensitive cell lines and primary cells.
• Viral Vector Production: Critical for optimizing the production of vaccines and therapeutics based on poxvirus vectors by suppressing antiviral cellular responses.
• Immunology Assays: Serves as a key component in assays designed to dissect interferon-mediated signaling pathways.
• Biopharmaceutical Development: Employed in R&D for novel oncolytic viruses and other viral immunotherapies.
• Diagnostic Reagent Manufacturing: Used in the production of high-specificity diagnostic kits for viral infections.

Basic Information

Product Name	B18R Protein, Vaccinia Virus
CAS No.	135847-80-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Vaccinia Virus B18R Protein; B18R IFN-α/β Binding Protein; VACV B18R; Type I Interferon Binding Protein; IFN-α/β Receptor Homolog; Recombinant Vaccinia Virus B18R; Viral Soluble Interferon Receptor; pAb-IFNAR2
EINECS	Contact for details

Quality Control

Our B18R Protein is produced under stringent conditions to ensure high purity, biological activity, and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including SDS-PAGE, HPLC, and functional bioassays. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Upon reconstitution, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or desiccated conditions when not in use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based assay)	Fully active
Identification (Mass Spec)	Conforms
Solubility	Soluble in aqueous buffers
Protein Concentration	As per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.