Description

Proton Pump Polypeptide 116K is a high-purity, biologically active peptide sequence designed for advanced research and development applications. This compound is critical for studies involving gastric acid secretion mechanisms and the function of H+/K+ ATPase enzymes. It serves as an essential tool for pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focused on gastroenterology, metabolic disorders, and novel therapeutic agent discovery.

Application

• Pharmaceutical Research & Development: As a key reference standard and active ingredient in the development of novel proton pump inhibitors and gastroprotective agents.
• Biochemical Assay Development: For use in in vitro enzymatic assays to study H+/K+ ATPase activity, inhibition kinetics, and mechanism of action studies.
• Academic & Clinical Research: A vital reagent for investigating the pathophysiology of acid-related disorders, such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.
• Diagnostic Kit Manufacturing: Used in the production of immunoassays and ELISA kits for the detection and quantification of related biomarkers.
• Preclinical Studies: Employed in animal model research to evaluate the efficacy and pharmacokinetics of new anti-secretory drug candidates.

Basic Information

Item	Detail
Product Name	Proton Pump Polypeptide 116K
CAS No.	135846-03-6
Molecular Formula	Contact for details
Molecular Weight	~116,000 Daltons (116K Da)
Synonyms	H+/K+ ATPase Polypeptide; Gastric Proton Pump Subunit; 116K Proton Pump Protein; HK-ATPase 116kDa Subunit; Acid Pump Polypeptide; (H+ + K+)-ATPase 116kDa Subunit; Gastric Mucosal Proton Transport Polypeptide
EINECS	Contact for details

Quality Control

Our Proton Pump Polypeptide 116K is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, identity confirmation via peptide mapping or mass spectrometry, and determination of biological activity. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Biological Activity	Assayed; Contact for details
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.