Description

Transcription Factor Hnf-4 CAS NO 135845-90-8 is a high-purity, biologically active protein critical for regulating gene expression. This nuclear receptor plays a fundamental role in metabolic pathways, making it an essential research tool for understanding liver function, diabetes, and lipid metabolism. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in metabolic disease research and drug discovery programs.

Application

• Drug Discovery & Target Validation: Used in high-throughput screening assays to identify and validate novel therapeutic compounds targeting metabolic disorders.
• Gene Regulation Studies: Essential for in vitro and cell-based studies investigating the transcriptional control of genes involved in glucose, lipid, and cholesterol homeostasis.
• Metabolic Disease Research: A key reagent for research into the molecular mechanisms of Type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and hyperlipidemia.
• Protein-Protein Interaction Analysis: Employed in studies to map interaction networks with co-activators, co-repressors, and other nuclear receptors.
• Diagnostic Development: Serves as a standard or component in the development of diagnostic assays for metabolic syndrome markers.
• Stem Cell Differentiation: Used in protocols to direct the differentiation of stem cells into hepatocyte-like cells for toxicology and disease modeling.

Basic Information

Product Name	Transcription Factor Hnf-4
CAS No.	135845-90-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hepatocyte Nuclear Factor 4-alpha; HNF4A; HNF4; HNF4α; NR2A1; Nuclear Receptor Subfamily 2 Group A Member 1; Transcription Factor 14; TCF14; MODY1; FRTS4
EINECS	Contact for details

Quality Control

Our Transcription Factor Hnf-4 is produced and tested under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity data. We adhere to relevant quality management guidelines to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Corresponds to expected molecular weight
Purity (SDS-PAGE)	> 90%
Endotoxin Level	< 1.0 EU/µg
Biological Activity (Gel Shift)	Confirmed binding to consensus DNA sequence
Protein Concentration	As per COA
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.