Description

Fmoc-3,4-Dehydro-Pro-Oh is a specialized, non-natural amino acid derivative used in advanced peptide synthesis. This compound is critical for introducing conformational constraints and structural diversity into peptide chains, enabling the development of novel bioactive molecules. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in drug discovery and peptide-based therapeutic development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of complex peptides.
• Conformationally Restricted Peptide Design: Used to incorporate a dehydroproline residue, which restricts backbone flexibility and stabilizes specific secondary structures.
• Drug Discovery & Medicinal Chemistry: Serves as a crucial intermediate in the development of peptide-based drug candidates, enzyme inhibitors, and receptor ligands.
• Biochemical Research: Employed in the study of protein folding, structure-activity relationships (SAR), and peptide-protein interactions.
• Combinatorial Chemistry Libraries: Used to create diverse peptide libraries for high-throughput screening against biological targets.
• Synthesis of Peptidomimetics: A building block for creating molecules that mimic the structure and function of natural peptides.

Basic Information

Product Name	Fmoc-3,4-Dehydro-Pro-Oh
CAS No.	135837-63-7
Molecular Formula	C₂₀H₁₇NO₄
Molecular Weight	335.35 g/mol
Synonyms	Fmoc-δ³-Pro-OH; (S)-N-(9-Fluorenylmethoxycarbonyl)-3,4-dehydropyrrolidine-2-carboxylic acid; Fmoc-(S)-3,4-Dehydroproline; Fmoc-dehydroproline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-didehydro-L-proline; Fmoc-Dhp-OH; Nα-Fmoc-3,4-dehydro-L-proline; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,4-didehydropyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-3,4-Dehydro-Pro-Oh is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.