Description

Ceftizoxime Alapivoxil is a prodrug ester of the third-generation cephalosporin antibiotic, Ceftizoxime, designed to enhance oral bioavailability. This compound is critical for the development of advanced oral dosage forms, offering a significant therapeutic advantage for systemic bacterial infections. It is primarily required by pharmaceutical R&D departments, formulation scientists, and manufacturers engaged in producing innovative antibiotic therapies.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key intermediate or active component in the synthesis of final oral antibiotic formulations.
• Antibacterial Drug Development: Used in research and development of new oral cephalosporin medications targeting a broad spectrum of Gram-positive and Gram-negative bacteria.
• Prodrug Synthesis: Acts as a model compound in studies focusing on prodrug technology to improve drug absorption and patient compliance.
• Clinical Research Materials: Supplied as a high-purity reference standard for pharmacokinetic, stability, and efficacy studies.
• Formulation Studies: Utilized in pre-formulation and formulation development for tablets, capsules, and other solid oral dosage forms.

Basic Information

Product Name	Ceftizoxime Alapivoxil
CAS No.	135821-54-4
Molecular Formula	C₂₀H₂₁N₉O₇S₂
Molecular Weight	563.57 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-[[(1,2,3-thiadiazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Pivaloyloxymethyl Ester; Ceftizoxime Pivaloyloxymethyl Ester; Ceftizoxime Alapivoxil; SQ 82,292; Alapivoxil Ceftizoxime
EINECS	Contact for details

Quality Control

Our Ceftizoxime Alapivoxil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) documenting full compliance with agreed specifications is provided with every shipment. We support development and commercial projects requiring material that meets GMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.