Description

Ceftizoxime Alapivoxil CAS NO 135767-36-1 is a prodrug ester of the third-generation cephalosporin antibiotic, Ceftizoxime, designed to enhance oral bioavailability. This compound is critical for the development of advanced pharmaceutical formulations targeting resistant bacterial infections. It is primarily required by pharmaceutical R&D departments, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global antibiotic market.

Application

• Pharmaceutical Active Ingredient (API): Serves as a key intermediate or the final active pharmaceutical ingredient in the synthesis of oral antibiotic formulations.
• Antibiotic Research & Development: Used in preclinical and clinical studies for developing new cephalosporin-based therapies against Gram-positive and Gram-negative bacteria.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Veterinary Medicine: Potential application in the development of antibacterial treatments for veterinary use.
• Combinatorial Chemistry: A valuable building block in medicinal chemistry for creating libraries of novel β-lactam compounds.

Basic Information

Product Name	Ceftizoxime Alapivoxil
CAS No.	135767-36-1
Molecular Formula	C₂₀H₂₁N₉O₇S₂
Molecular Weight	563.57 g/mol
Synonyms	Ceftizoxime Alapivoxil; (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-[[(1,2,3-thiadiazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1-(acetyloxy)ethyl ester; Ceftizoxime axetil (common alias); FK-749; SQ-81015; 1-Acetoxyethyl (6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7²-(Z)-(O-methyloxime) acetate (ester)
EINECS	Contact for details

Quality Control

Our Ceftizoxime Alapivoxil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment with minimal exposure to humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.