Description

Bradykinin, Acetyl-Arg-Hyp(3)-Phe(7)-Leu(8)- is a chemically modified, stabilized analog of the endogenous peptide bradykinin. This compound is of significant value for research and development due to its enhanced stability and specific receptor interaction profile compared to the native peptide. It is primarily needed by pharmaceutical researchers, biochemical laboratories, and academic institutions focused on cardiovascular physiology, inflammation, pain pathways, and the development of novel therapeutic agents targeting the kallikrein-kinin system.

Application

• Biomedical Research: Used as a critical tool compound for studying the role of bradykinin B1 and B2 receptors in various physiological and pathological processes.
• Drug Discovery & Development: Serves as a reference standard or a lead structure in the development of receptor agonists/antagonists for conditions like hypertension, inflammation, and neuropathic pain.
• In Vitro Assays: Employed in cell-based assays (e.g., calcium flux, IP3 accumulation) to characterize receptor signaling and screen for modulators.
• Signal Transduction Studies: Utilized to investigate downstream signaling cascades involving G-proteins, phospholipase C, and nitric oxide synthase.
• Pharmacology & Toxicology: Acts as a control substance in studies examining vascular permeability, smooth muscle contraction, and nociception.
• Biochemical Reagent: Functions as a high-purity substrate or ligand in enzymatic studies and receptor binding assays (competitive displacement).

Basic Information

Product Name	Bradykinin, Acetyl-Arg-Hyp(3)-Phe(7)-Leu(8)-
CAS No.	135705-19-0
Molecular Formula	C52H78N16O12
Molecular Weight	1103.3 g/mol
Synonyms	Acetyl-[Hyp3, Phe7, Leu8]-Bradykinin; Acetyl-Hyp3,Phe7,Leu8-Bradykinin; [Acetyl-Hyp3,Phe7,Leu8]-BK; Bradykinin Potentiator B; Stabilized Bradykinin Analog; BK (1-9) analog; B 4146; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Bradykinin, Acetyl-Arg-Hyp(3)-Phe(7)-Leu(8)- is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (AAA)	≥ 97% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Single Impurity (HPLC)	≤ 2.0 %
Biological Activity	Confirmed by in vitro assay (Reported on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.