Description

15-Keto Latanoprost is a key pharmaceutical intermediate and a metabolite of the prostaglandin analog Latanoprost. This compound is of significant interest for research and development in the ophthalmic pharmaceutical sector, particularly for the synthesis and analytical study of glaucoma treatments. It serves as a critical reference standard and building block for manufacturers and research institutions focused on developing and quality-controlling prostaglandin-based therapeutics.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced prostaglandin analogs and related ophthalmic APIs.
• Analytical Reference Standard: Essential for HPLC, LC-MS, and other chromatographic methods to quantify Latanoprost and its metabolites in drug substances and finished products.
• Metabolite Studies: Used in pharmacokinetic and pharmacodynamic research to understand the metabolism and efficacy of Latanoprost.
• Process Development & Validation: Critical for developing and validating manufacturing processes for prostaglandin-based drugs under GMP guidelines.
• Quality Control Laboratories: Employed as a high-purity standard to ensure the identity, potency, and purity of commercial Latanoprost batches.
• Biochemical Research: Tool compound for investigating the biological pathways and receptor interactions of prostaglandins.

Basic Information

Product Name	15-Keto Latanoprost
CAS No.	135646-98-9
Molecular Formula	C₂₆H₄₀O₅
Molecular Weight	432.60 g/mol
Synonyms	15-Oxo Latanoprost; Latanoprost 15-Ketone; 15-Keto-13,14-dihydro Latanoprost; (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic Acid Isopropyl Ester 15-Ketone; 15-Keto Latanoprost Acid Isopropyl Ester; Prosta-5,13-dien-1-oic Acid Derivative; Latanoprost Metabolite
EINECS	Contact for details

Quality Control

Our 15-Keto Latanoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C to 25°C (59°F to 77°F), in a dry environment. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.