Description

(5-Fluoro-2,3-Dihydrobenzofuran-2-Yl)Methanol is a high-value fluorinated benzofuran derivative, serving as a critical chiral building block in advanced organic synthesis. Its importance lies in its unique fused-ring structure and fluorine substitution, which are essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Development: Used as a precursor for novel herbicides and fungicides, leveraging the fluorine atom for enhanced efficacy and environmental stability.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Serves as a monomer or functional additive in the development of advanced polymers with specific optical or electronic properties.
• Chemical Biology Probes: Utilized to create fluorinated probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	(5-Fluoro-2,3-Dihydrobenzofuran-2-Yl)Methanol
CAS No.	135634-27-4
Molecular Formula	C9H9FO2
Molecular Weight	168.16 g/mol
Synonyms	2-(Hydroxymethyl)-5-fluoro-2,3-dihydrobenzofuran; 5-Fluoro-2,3-dihydro-2-benzofuranmethanol; (5-Fluoro-2,3-dihydrobenzofuran-2-yl)methanol; 5-Fluoro-2-(hydroxymethyl)-2,3-dihydrobenzofuran; 2,3-Dihydro-5-fluorobenzofuran-2-methanol; (5-Fluoro-2,3-dihydro-1-benzofuran-2-yl)methanol; 135634-27-4 (CAS Name)
EINECS	Contact for details

Quality Control

Our (5-Fluoro-2,3-Dihydrobenzofuran-2-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are provided with every shipment. We support compliance with ICH guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.