Description

Phospholemman is a small transmembrane regulatory protein that plays a critical role in modulating cardiac ion transport and contractility. This compound is essential for fundamental research in cardiovascular physiology and pathophysiology, particularly in studies of heart failure and ischemia-reperfusion injury. It is a key reagent for researchers and pharmaceutical developers in the fields of cardiac biology, molecular pharmacology, and drug discovery targeting ion channel function.

Application

• Cardiovascular Research: Fundamental studies on the regulation of the Na+/K+-ATPase and sodium-calcium exchanger in cardiac myocytes.
• Molecular Pharmacology: Investigation of protein kinase signaling pathways (e.g., PKA, PKC) and their effects on cardiac ion homeostasis.
• Drug Discovery & Development: Used as a target or tool compound in screening assays for novel cardioprotective or heart failure therapeutics.
• Biochemical Assays: Purified protein for use in in vitro binding studies, enzyme activity assays, and structural analysis.
• Antibody Production: Serving as an antigen for the generation of specific antibodies used in Western blotting, immunohistochemistry, and ELISA.
• Educational & Diagnostic Tool: Utilized in academic settings and diagnostic kit development for understanding cardiac muscle function.

Basic Information

Product Name	Phospholemman
CAS No.	135541-82-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PLM; FXYD1; Mat-8; Membrane protein FXYD1; Phospholemman-like protein; FXYD domain-containing ion transport regulator 1
EINECS	Contact for details

Quality Control

Our Phospholemman is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for identity and purity using advanced analytical techniques. Certificates of Analysis (COA) detailing purity, biological activity (where applicable), and storage stability are provided and available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Biological Activity	Assessed by functional assay
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in specific aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.