Description

Muscarinic Toxin 2 CAS NO 135541-77-4 is a highly selective, high-affinity peptide toxin derived from the venom of the green mamba snake (*Dendroaspis angusticeps*). This compound serves as a critical pharmacological tool for the specific and irreversible antagonism of the M1 muscarinic acetylcholine receptor subtype. It is essential for researchers in neuroscience, pharmacology, and drug discovery who require precise molecular probes to study cholinergic signaling pathways, receptor function, and for the development of targeted neurological therapeutics.

Application

• Neuroscience Research: A key tool for studying the role of M1 receptors in learning, memory, and cognitive function.
• Pharmacological Profiling: Used to selectively block M1 receptor activity in vitro and in vivo to understand receptor-specific effects.
• Drug Discovery & Development: Employed in high-throughput screening and validation assays for novel muscarinic receptor-targeting compounds.
• Signal Transduction Studies: Facilitates research into G-protein coupled receptor (GPCR) signaling cascades initiated by muscarinic receptors.
• Receptor Subtype Characterization: Essential for distinguishing the functional contributions of M1 receptors from other muscarinic subtypes (M2-M5).
• Toxicology & Venom Research: Studied as a component of mamba venom for understanding its mechanism of action and potential therapeutic applications.

Basic Information

Product Name	Muscarinic Toxin 2
CAS No.	135541-77-4
Molecular Formula	C185H281N55O53S7
Molecular Weight	~4250 g/mol
Synonyms	MT2; Muscarinic Toxin MT2; Dendrotoxin I; Toxin F; M1-Toxin; M1 Receptor Antagonist Toxin; *Dendroaspis angusticeps* Toxin 2; Muscarinic Acetylcholine Receptor M1 Antagonist
EINECS	Contact for details

Quality Control

Our Muscarinic Toxin 2 is produced and purified under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is characterized using advanced analytical techniques, including mass spectrometry for molecular weight confirmation and HPLC for purity assessment. A comprehensive Certificate of Analysis (COA) detailing purity, potency (specific activity), and endotoxin levels is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.