Description

Isonicotinoylhydrazine Glucuronide is a specialized glucuronide conjugate of isonicotinoylhydrazine, a key metabolite of the first-line anti-tuberculosis drug isoniazid. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug metabolism, bioanalytical method development, and regulatory toxicology.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantification of isoniazid metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS or HPLC.
• Pharmacokinetic & Metabolism Studies: Essential for investigating the metabolic pathways, clearance rates, and bioavailability of isoniazid in preclinical and clinical research.
• Toxicology and Safety Assessment: Used to study the formation and potential toxicity of drug metabolites, supporting regulatory submissions for drug safety profiles.
• Diagnostic Assay Development: Acts as a calibrator or control in the development of diagnostic kits for therapeutic drug monitoring (TDM) of tuberculosis patients.
• Academic Research: Employed in universities and research institutes for fundamental studies on glucuronidation enzymes (UGTs) and drug-drug interactions.

Basic Information

Product Name	Isonicotinoylhydrazine Glucuronide
CAS No.	135467-94-6
Molecular Formula	C₁₂H₁₅N₃O₇
Molecular Weight	313.26 g/mol
Synonyms	Isoniazid Glucuronide; Isonicotinoylhydrazine β-D-Glucuronide; N'-Isonicotinoylhydrazine Glucuronide; Isoniazid Metabolite Glucuronide; 4-Pyridinecarboxylic Acid Hydrazide Glucuronide; INH-Glucuronide; Glucuronide Conjugate of Isoniazid
EINECS	Contact for details

Quality Control

Every batch of Isonicotinoylhydrazine Glucuronide is manufactured and tested under strict quality management systems. We provide high-purity material suitable for use as an analytical reference standard, with comprehensive characterization including HPLC purity, NMR, and MS confirmation. A detailed Certificate of Analysis (COA) containing batch-specific data is supplied with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.