Description

Mlck Peptide CAS NO 135467-90-2 is a high-purity, synthetic peptide inhibitor of myosin light chain kinase (MLCK), a key enzyme in the regulation of smooth muscle contraction and endothelial cell function. This compound is a critical research tool for investigating cellular signaling pathways related to vascular tone, inflammation, and barrier function. It is primarily utilized by researchers and developers in the fields of pharmacology, cardiovascular research, and cell biology for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of MLCK in smooth muscle contraction and cytoskeletal dynamics.
• Cardiovascular Studies: Employed in research models to investigate hypertension, vasospasm, and vascular permeability.
• Cell Signaling Pathways: A key reagent for dissecting calcium/calmodulin-dependent signaling cascades in endothelial and epithelial cells.
• Drug Discovery & Target Validation: Serves as a reference standard and pharmacological tool in pre-clinical development of therapeutics targeting MLCK.
• Academic & Institutional Research: Essential for basic science investigations into non-muscle myosin II regulation and cell motility.

Basic Information

Product Name	Mlck Peptide
CAS No.	135467-90-2
Molecular Formula	C42H71N13O12
Molecular Weight	926.1 g/mol
Synonyms	MLCK Inhibitor Peptide 18; Myosin Light Chain Kinase Inhibitor Peptide; MLCK Peptide Inhibitor; [Lys21, Arg22, Phe23, Trp24]-MLC Peptide; SM-1; SM1 Peptide; Calmodulin-dependent Myosin Light Chain Kinase Substrate Peptide; MLCK Substrate Analog
EINECS	Contact for details

Quality Control

Our Mlck Peptide is manufactured under strict quality protocols suitable for research applications. Each batch is characterized by advanced analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and mass spectrometry data are provided to guarantee it meets the stringent requirements of life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.