Description

Neuromedin C, Ala(1)-Leu(9)-Psi-(Ch2Nh)-Leu(10)- is a synthetic, biologically active peptide analog of neuromedin C, also known as the C-terminal decapeptide of gastrin-releasing peptide (GRP). This compound is specifically engineered with a reduced peptide bond (Psi-(Ch2Nh)) between residues 9 and 10, enhancing its metabolic stability and making it a valuable tool for receptor binding studies and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers in the fields of neurobiology, oncology, and gastrointestinal physiology. The product is supplied as a high-purity material to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: Used as a potent and selective agonist for the gastrin-releasing peptide receptor (GRPR) in signal transduction and cell proliferation studies.
• Neuropharmacology: Investigation of neuromedin C's role in the central and peripheral nervous systems, including its effects on smooth muscle contraction and neurotransmitter release.
• Oncology Research: Study of GRPR expression and function in various cancer models, particularly prostate, breast, and lung cancers, for potential therapeutic targeting.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel diagnostic agents and therapeutics targeting bombesin receptor subtypes.
• Biochemical Assays: Employed in competitive binding assays, receptor autoradiography, and functional studies to characterize receptor affinity and efficacy.
• Academic & Institutional Studies: Fundamental research into the physiological roles of bombesin-like peptides in digestion, satiety, and stress response.

Basic Information

Product Name	Neuromedin C, Ala(1)-Leu(9)-Psi-(Ch2Nh)-Leu(10)-
CAS No.	135467-89-9
Molecular Formula	C53H84N16O13
Molecular Weight	1129.3 g/mol
Synonyms	Ala(1)-Leu(9)-[Psi-(CH2NH)]-Leu(10)-Neuromedin C; [Ala1, ψ(CH2NH)Leu9-10]Neuromedin C; GRP(18-27), Ala1-ψ(CH2NH)Leu9-10-; Reduced Peptide Bond Neuromedin C Analog; Bombesin Receptor Agonist (GRPR); Gastrin-Releasing Peptide Fragment (18-27) Analog; Ala-Leu-ψ(CH2NH)-Leu-Neuromedin C
EINECS	Contact for details

Quality Control

Our Neuromedin C analog is manufactured under strict quality control protocols to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment. We adhere to GMP-like guidelines for peptide synthesis to guarantee batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. Solutions should be prepared in appropriate buffers and used immediately or aliquoted and stored frozen for single use to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.