Description

(R)-2-Hydroxy-2-Methyl-Hexanenitrile is a high-value, chiral nitrile compound featuring a stereogenic center at the carbon bearing the hydroxyl group. This molecule is a critical chiral building block and synthetic intermediate, prized for its ability to introduce both functional complexity and optical purity into target molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of complex drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric catalysis (e.g., Henry reactions, cyanation).
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Process Chemistry Research: A valuable tool for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	(R)-2-Hydroxy-2-Methyl-Hexanenitrile
CAS No.	135415-89-3
Molecular Formula	C7H13NO
Molecular Weight	127.18 g/mol
Synonyms	(R)-2-Methyl-2-hydroxyhexanenitrile; (R)-2-Hydroxy-2-methylcapronitrile; (2R)-2-Hydroxy-2-methylhexanenitrile; (R)-α-Hydroxyisocapronitrile; Hexanenitrile, 2-hydroxy-2-methyl-, (R)-; (R)-2-Hydroxy-2-methylpentyl cyanide
EINECS	Contact for details

Quality Control

We supply (R)-2-Hydroxy-2-Methyl-Hexanenitrile in high chemical and optical purity grades suitable for demanding synthetic applications. Every batch is characterized by advanced analytical techniques including chiral HPLC to ensure enantiomeric excess (ee) and chemical purity meet stringent specifications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and optical rotation is provided with each shipment, supporting compliance with internal quality standards and research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Optical Rotation	To be provided on COA
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.