Description

Hemoglobin F Charlotte is a specific variant of fetal hemoglobin, a critical protein for oxygen transport. This high-purity biochemical is essential for advanced research and diagnostic applications where precise molecular characterization is required. It is primarily utilized by researchers in hematology, biochemistry, and clinical diagnostics for studying hemoglobinopathies, developing reference standards, and creating specialized assays.

Application

• Biochemical Research: Used as a high-purity standard and reagent in studies of fetal hemoglobin structure, function, and genetic regulation.
• Diagnostic Development: Serves as a critical component in the calibration and validation of diagnostic assays for hemoglobin disorders like sickle cell disease and thalassemia.
• Reference Material: Acts as a certified reference material (CRM) in clinical laboratories to ensure the accuracy of chromatographic and electrophoretic techniques.
• Pharmaceutical Research: Employed in drug discovery and development projects targeting sickle cell disease, where modulating fetal hemoglobin levels is a therapeutic strategy.
• Quality Control: Used by in-vitro diagnostic (IVD) manufacturers for the quality control of hemoglobin testing systems and reagents.

Basic Information

Product Name	Hemoglobin F Charlotte
CAS No.	135403-15-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hb F Charlotte; Fetal Hemoglobin Charlotte; Hemoglobin F (Charlotte variant); γ-globin variant Charlotte; HbF Charlotte; Gly->Asp variant at γ-75; γ75(E19)Gly->Asp; HBF CHARLOTTE
EINECS	Contact for details

Quality Control

Our Hemoglobin F Charlotte is produced and handled under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC and identity confirmation via mass spectrometry, to ensure it meets the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing all test parameters and results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Handle under controlled conditions to prevent denaturation or degradation.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content	Determined by UV-Vis
Solubility	Clear solution in appropriate buffer
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.