Description

Proteingeranylgeranyltransferase CAS NO 135371-29-8 is a specialized enzyme critical for the post-translational modification of proteins, specifically catalyzing the transfer of a geranylgeranyl group to cysteine residues. This modification is essential for the proper membrane localization and biological activity of numerous signaling proteins, including those in the Ras superfamily. It is a vital research tool for biochemists, molecular biologists, and pharmaceutical scientists investigating signal transduction pathways, cancer biology, and the development of targeted therapeutics.

Application

• Biochemical Research: Essential for in vitro studies of protein prenylation mechanisms and enzyme kinetics.
• Drug Discovery & Screening: Used as a target enzyme in high-throughput assays to identify and characterize novel inhibitors for cancer and other diseases.
• Signal Transduction Studies: Employed to modify recombinant proteins to study the role of geranylgeranylation in cellular localization and function.
• Academic & Pharmaceutical R&D: A key reagent for investigating fundamental biological processes and validating therapeutic targets in oncology and neurology.
• Enzyme Characterization: Used to study substrate specificity, catalytic activity, and the structural biology of prenyltransferases.

Basic Information

Product Name	Proteingeranylgeranyltransferase
CAS No.	135371-29-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Protein Geranylgeranyltransferase; Geranylgeranyltransferase I; GGTase I; Rab Geranylgeranyltransferase; Prenyltransferase; Farnesyltransferase Type II; CAAX Prenyltransferase 2; EC 2.5.1.59
EINECS	Contact for details

Quality Control

Our Proteingeranylgeranyltransferase is produced and handled under stringent quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity, specific activity, and functional integrity. Certificates of Analysis (COA) detailing purity (by SDS-PAGE), activity assays, and storage buffer composition are available upon request to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. Use within the expiration date stated on the label when stored under these recommended conditions.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Purity (SDS-PAGE)	≥ 90%
Specific Activity	Contact for details
Protein Concentration	Contact for details
Buffer Composition	Tris-HCl, Glycerol, DTT, NaCl
Storage Buffer	pH 7.5 - 8.0
Endotoxin Level	< 1.0 EU/µg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.