Description

1(3)-Pyrenebutanoyl-2,3(1,2)-Dipalmitoyl-Sn-Glycerol CAS NO 135328-05-1 is a synthetic, fluorescently-labeled glycerolipid derivative, specifically designed for advanced research applications. This compound is critical for studying lipid dynamics, membrane biophysics, and intracellular trafficking due to its pyrene fluorophore, which enables sensitive detection via fluorescence spectroscopy and microscopy. It is an essential tool for researchers and developers in pharmaceutical R&D, biochemical assay development, and advanced material science, where precise tracking of lipid molecules is required.

Application

• Fluorescent Lipid Probes: Used as a critical component in the development of fluorescent probes for studying lipid bilayer properties, membrane fluidity, and fusion events.
• Biomembrane Research: Serves as a tracer in model membrane systems (e.g., liposomes, supported lipid bilayers) to investigate lipid-protein interactions and domain formation.
• Cell Biology & Trafficking Studies: Employed to visualize and track the intracellular transport, metabolism, and localization of neutral lipids and lipid droplets.
• Drug Delivery System Development: Incorporated into lipid-based nanoparticle formulations (e.g., LNPs, liposomes) as a diagnostic marker to monitor carrier stability, biodistribution, and targeting efficiency.
• Analytical Method Development: Acts as a high-purity standard or reference compound in chromatographic (HPLC, TLC) and spectroscopic (fluorescence, UV) analytical methods for lipid analysis.
• Biophysical Assays: Utilized in Förster resonance energy transfer (FRET) and other fluorescence-based assays to measure molecular distances and interactions within lipid environments.

Basic Information

Product Name	1(3)-Pyrenebutanoyl-2,3(1,2)-Dipalmitoyl-Sn-Glycerol
CAS No.	135328-05-1
Molecular Formula	C61H92O6
Molecular Weight	921.38 g/mol
Synonyms	Pyrene-labeled Dipalmitoylphosphatidylcholine analog; 1-Pyrenebutyryl-2,3-dipalmitoyl-rac-glycerol; 1-Pyrenebutanoyl-2,3-dipalmitoyl-sn-glycerol; 3-Pyrenebutanoyl-1,2-dipalmitoyl-sn-glycerol; Fluorescent DPPG analog; N-(Pyrenebutyryl)-dipalmitoylphosphatidylethanolamine (common misnomer); Pyrene-C4-Dipalmitin; sn-Glycerol, 1-(4-pyrenebutanoyl)-2,3-dihexadecanoyl-
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical is governed by stringent quality protocols to ensure batch-to-batch consistency and research-grade purity. Each lot undergoes comprehensive analysis including HPLC for purity assessment, NMR and MS for structural confirmation, and fluorescence spectroscopy for functional validation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to ISO 9001 quality management principles to support reliable outcomes in sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is light-sensitive (store away from light) and should be allowed to warm to room temperature in the dark before opening to prevent condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to light brown solid or waxy solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95% (Area Percent)
Pyrene Content (Fluorescence)	Confirmed
Solubility	Soluble in chloroform, DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.