Description

Gadoxetic Acid is a paramagnetic contrast agent primarily used in magnetic resonance imaging (MRI). This compound is a key pharmaceutical intermediate for the synthesis of gadolinium-based contrast agents, which are critical for enhancing the visibility of internal body structures during diagnostic scans. It is essential for manufacturers in the pharmaceutical and diagnostic imaging industries who require high-purity, reliable materials for producing advanced medical imaging products.

Application

• Primary Pharmaceutical Intermediate: Synthesis of Gadoxetate Disodium (Gd-EOB-DTPA), a liver-specific MRI contrast agent.
• Diagnostic Imaging Agent Production: Manufacturing of contrast media for enhanced magnetic resonance imaging (MRI) of the liver and bile ducts.
• Research & Development: Used in biochemical and pharmacological research for developing new diagnostic agents and studying hepatobiliary function.
• Radiopharmaceuticals: Serves as a chelating agent precursor for other gadolinium-based complexes used in various MRI applications.

Basic Information

Product Name	Gadoxetic Acid
CAS No.	135326-11-3
Molecular Formula	C23H34GdN3O11
Molecular Weight	675.70 g/mol
Synonyms	Gadolinium-EOB-DTPA; Gd-EOB-DTPA; EOB-DTPA-Gd; Gadoxetate Acid; (4S)-4-(4-Ethoxybenzyl)-3,6,9-tris(carboxymethyl)-3,6,9-triazaundecanedioic acid gadolinium complex; Primovist Intermediate; MultiHance Intermediate (related compound); Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid
EINECS	Contact for details

Quality Control

Our Gadoxetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, ICP-MS for heavy metal and gadolinium content, and tests for residual solvents and related substances, ensuring it meets stringent standards for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with every shipment, and we can support compliance with GMP, ICH Q7, and relevant pharmacopeial guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Free Gadolinium (ICP-MS)	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH limits
Water Content (KF)	≤ 2.0%
pH (in solution)	6.5 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.