Description

4-[(2R)-2-(3,4,5,6-Tetrahydro-2H-Pyran-2-Yloxy)-Propionyl]Morpholine is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) where stereochemical control is critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in stereoselective chemical reactions to introduce specific chiral centers.
• Process Chemistry: Employed in route scouting, optimization, and scale-up for the manufacturing of complex organic molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for the discovery and development of new drug candidates in R&D laboratories.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	4-[(2R)-2-(3,4,5,6-Tetrahydro-2H-Pyran-2-Yloxy)-Propionyl]Morpholine
CAS No.	135270-08-5
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	(2R)-2-(3,4,5,6-Tetrahydro-2H-pyran-2-yloxy)-1-(4-morpholinyl)-1-propanone; 4-[(2R)-2-(3,4,5,6-Tetrahydro-2H-pyran-2-yloxy)propanoyl]morpholine; Morpholine, 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-1-oxopropyl]-; (R)-2-(3,4,5,6-Tetrahydro-2H-pyran-2-yloxy)-1-morpholinopropan-1-one; THP-protected chiral morpholine derivative; Chiral THP ether of morpholinopropanone
EINECS	Contact for details

Quality Control

Our production of 4-[(2R)-2-(3,4,5,6-Tetrahydro-2H-Pyran-2-Yloxy)-Propionyl]Morpholine adheres to stringent quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the required specifications. Certificates of Analysis (COA) detailing comprehensive analytical results, including chiral purity by HPLC, are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.