Description

1H-Pyrrole-3-Carbonitrile, 5-(Trifluoroacetyl)- (9Ci) is a high-value, multi-functional heterocyclic building block characterized by its pyrrole core, nitrile group, and trifluoroacetyl substituent. This compound matters for its role as a critical synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, where its unique structure enables the introduction of key pharmacophores. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrrole moiety.
• Material Science Precursor: Serves as a monomer or precursor for conducting polymers and advanced organic electronic materials due to its electron-rich pyrrole structure.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal catalysis and asymmetric synthesis in fine chemical manufacturing.
• Fluorinated Compound Research: Essential for introducing the trifluoromethyl group into target molecules, a common strategy in medicinal chemistry to improve metabolic stability and bioavailability.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of specialized heterocyclic dyes and pigments for high-performance applications.

Basic Information

Product Name	1H-Pyrrole-3-Carbonitrile, 5-(Trifluoroacetyl)- (9Ci)
CAS No.	135250-38-3
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	5-(Trifluoroacetyl)-1H-pyrrole-3-carbonitrile; 5-Trifluoroacetyl-3-cyanopyrrole; 3-Cyano-5-trifluoroacetylpyrrole; 1H-Pyrrole-3-carbonitrile, 5-(trifluoroacetyl)-; 5-(Trifluoroacetyl)-3-pyrrolecarbonitrile; Pyrrole-3-carbonitrile, 5-(trifluoroacetyl)-; 135250-38-3 (CAS)
EINECS	Contact for details

Quality Control

Our 1H-Pyrrole-3-Carbonitrile, 5-(Trifluoroacetyl)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.