Description

5-Cyano-2,2-Difluoro-1,3-Benzodioxole is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzodioxole scaffold with cyano and difluoro substituents. This compound is of significant commercial value for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought after by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in medicinal chemistry programs for CNS and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its fluorinated structure for enhanced bioactivity and stability.
• Material Science Precursor: Serves as a monomer or precursor in the development of specialty polymers and advanced organic electronic materials.
• Organic Synthesis Reagent: Employed in academic and industrial research for constructing complex heterocyclic compounds and fluorinated analogs.
• Ligand and Catalyst Development: Utilized in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Cyano-2,2-Difluoro-1,3-Benzodioxole
CAS No.	135132-34-2
Molecular Formula	C8H3F2NO2
Molecular Weight	183.11 g/mol
Synonyms	2,2-Difluoro-1,3-benzodioxole-5-carbonitrile; 1,3-Benzodioxole-5-carbonitrile, 2,2-difluoro-; 5-Cyano-2,2-difluorobenzodioxole; 2,2-Difluoro-5-cyanobenzodioxole; Difluorobenzodioxolecarbonitrile; 135132-34-2 (CAS); 5-CN-2,2-F2-BD
EINECS	Contact for details

Quality Control

Our 5-Cyano-2,2-Difluoro-1,3-Benzodioxole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each shipment. We adhere to cGMP principles where applicable to ensure supply chain reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.